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SAN FRANCISCO -- The Carolina Panthers can now say they have that signature win everybody has been waiting to see: on the road, against the reigning NFC champions, in November. While facing one of the NFLs brightest young quarterbacks, to boot. Carolinas swarming, opportunistic defence stopped Colin Kaepernick in his tracks. Drayton Florence intercepted a pass by Kaepernick in the final minute to seal a 10-9 victory Sunday to snap the San Francisco 49ers five-game winning streak and give the Panthers their fifth straight win. So much for the idea that Carolina hadnt beaten any team of consequence thus far. "I dont think it really bothers us, it gives us the opportunity to step up to the challenge. We did," said wide receiver Steve Smith, who had six receptions. "A win like this can boost us, a win like this can continue to give us life throughout the season, and make us feel like were working for something, and we are." Graham Gano kicked a 53-yard field goal with 10:05 remaining that held up as the Panthers (6-3) twice shut down Kaepernick on last-ditch drives with swarming defence. DeAngelo Williams broke two tackles for a 27-yard touchdown run late in the first half that pulled Carolina within 9-7. Gano missed wide left on a 48-yard field goal in the third period, but came through later. San Francisco (6-3) got the ball back with 5:25 left at its 1, then again with 1:02 to go. Phil Dawson kicked a season-best 52-yard field goal among his three for the 49ers, who lost tight end Vernon Davis and rookie safety Eric Reid to concussions. Carolina fumbled twice in the closing moments, but recovered each time. First, Jonathan Stewart fumbled and Mike Tolbert pounced on the ball. Cam Newton recovered his own bobble. This was hardly the highly touted showdown between 2011 No. 1 overall pick Newton and Kaepernick, the sixth quarterback drafted that year, in the second round. They roomed together during the scouting combine. For Newton, the numbers hardly mattered. "This game is a maturity jump for us, because in the past what Ive been a part of, weve been somewhat uncertain of how we will turn out in these types of games," Newton said. "We needed that type of game, just to be in a dog fight, in somewhat of a barnburner, to show what type of team this really is." Kaepernick went 11 for 22 for 91 yards with an interception and was sacked six times for a 42.0 passer rating. Newton was only slightly better, going 16 of 32 for 169 yards, an interception and four sacks for a 52.7 rating. For two teams that have been putting up points at a prolific pace for the past month, the defences dictated this one. "As the game went on, it got more and more intense," Smith said. More than losing the game, the 49ers losses of Davis and Reid could be troublesome for the reigning NFC champions as they hit the road next week for New Orleans, then go to Washington. "Well do what we do, bounce back, regroup, refit and reorganize and come back this week," coach Jim Harbaugh said. Davis didnt return after sustaining a concussion in the second quarter, then Reid went down on a helmet-to-helmet hit on Mike Tolbert in the third. Earlier, Reid recovered a fumble to give him five takeaways in an already-stellar rookie season that also includes three interceptions. Frank Gore had 16 carries for 82 yards, accounting for most of San Franciscos 151 total yards. "For the most part, I dont really think they did anything that necessarily confused us," 49ers centre Jonathan Goodwin said. "They only gave up nine points. Its hard not to give them credit. We expected it to be a physical game. Did we expect to only score nine points? Nah." Dawson put San Francisco ahead on a 52-yard field goal on the teams opening drive, then kicked second-quarter field goals of 43 and 25 yards. But Kaepernick could never get his team in the end zone in its first game since a bye on the heels of a win over Jacksonville in London. 49ers pass-rushing specialist and 2012 All-Pro linebacker Aldon Smith played limited snaps after missing five games to undergo treatment for substance abuse. Wide receiver Mario Manningham started and had three catches in his season debut, nearly 11 months after a serious left knee injury that required surgery. Carolina got going after managing only minus-7 yards passing and 12 total yards in the first quarter. The Panthers finished with 250 total yards. "This one really did come down to the way the defence played," Panthers coach Ron Rivera said. "Any time you put yourself in a position where you can force the other team to kick field goals, you get a chance to win." Notes: The 49ers also lost TE Garrett Celek to a hamstring injury in the first quarter, while DT Ray McDonald hurt an ankle. ... Panthers LB Chase Blackburn did not return in the second half because of a foot injury. Adidas X_Plr NZ . -- Kevin Stadler might be playing in the Masters for the first time, but hes already showing his old man a thing or two. Adidas Falcon New Zealand .com) - The Carolina Hurricanes hope to remain perfect at home in January on Friday night as they welcome the Vancouver Canucks to PNC Arena. http://www.nmdshoesnz.com/adidas-nmd-r2-cheap-nz.html . - Hitting was supposed to be the Pittsburgh Pirates weakness coming into the season yet they lead the major leagues in home runs through the first 16 games of the season. Adidas NMD R1 Mens NZ .J. Ward appeared in court Friday on misdemeanour charges that he threw a glass mug at a bartender at a Denver strip club. Cheap NMD NZ . The result was a game-winning, power-play goal. Chiasson snapped a third-period tie and lifted the Dallas Stars to a 3-2 victory on Monday night.Adam Scott is looking for a caddie now that he and Steve Williams have decided to end their partnership. Scott said in a statement Wednesday that he and Williams are at different stages of their lives. Williams has been on the bag for 14 majors -- 13 with Tiger Woods. He began working with Scott in the summer of 2012. He helped read the putt on the 110th hole at Augusta National last year when Scott became the first Australian to win the Masters.dddddddddddd Williams lives in New Zealand and has said he wants to cut back on his schedule. He says it became clear his plan was not going to fit with what Scott wanted. Williams said he would consider part-time work if the right job came along. ' ' '